Connective tissue activation

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Connective Tissue Activation

A polypeptide which induces hypermetabolism in normal synovial fibroblasts in tissue culture is described. The metabolic changes induced included a marked increase in hyaluronate formation, lactate formation and glucose uptake; formation of soluble and fibrous collagen was depressed. An assay method is presented which permits quantitative comparisons of samples for connective tissue activating ...

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1362 Connective Tissue Activation

14 C-gldcommine and '5S04-labeled glycosaminoglycan (GAG) synthesis, 2) responsiveness to autacdid mediators, and 3) perfarmance following maximal stimulation. Under basal conditions, SF synthesized and secreted 2-3 times more radioactive hyaluronic acid than the NF (P < 0.001); molecular volume by gel chromatography was similar and suggested a high molecular weight ptoduct. SF were essentially...

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Connective tissue activation. XXVIII. A connective tissue activating peptide from human urine.

A protein factor in human urine which has the ability to activate connective tissue cells has been identified and partially purified; it appears to be different from epidermal growth factor and IgG. This urinary connective tissue activating factor (CTAP-U) is nondialyzable, labile to protease, stable to thiols, heat, and acid, and has an acidic isoelectric point. Purified preparations of CTAP-U...

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Artificial Activation of the Growth in Vitro of Connective Tissue

The experiments have shown that extracts of tissues and tissue juices, under certain conditions, accelerate the growth in intro of the connective tissue from about three to forty times. This activating power was found in many tissues. It was much more marked, however, with the extracts of embryos, of adult spleen, and of the Rous sarcoma. The power diminished directly with the dilution of the e...

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ژورنال

عنوان ژورنال: Arthritis & Rheumatism

سال: 1983

ISSN: 0004-3591,1529-0131

DOI: 10.1002/art.1780260411